In a previous study, we observed that health-related quality of life was similar in adult women with Turner syndrome treated with GH in childhood and the general population (11).We identified several components of the disease or consequences of medical management as factors associated with low health-related quality of life scores: cardiac and otological involvement, induction of puberty after the age of 15 yr, and higher expectations from GH treatment.Data from the questionnaire were entered in the database with the coded identifier but without the personally identifying information, allowing us to keep this confidential information anonymous.
It is therefore important to analyze the influence of management options in childhood on these dimensions to help pediatricians make the best choices concerning the management of their patients.
The factors determining the onset of sexuality in humans are poorly characterized, and attention has mostly focused on behavioral, environmental, and psychosocial determinants (16).
The Association France-Hypophyse database is nominative, which allowed mailing the questionnaires.
A coded identifier was included to medical data exported to the study database and the questionnaires.
In this study, we evaluated self-esteem, social adjustment, and sexuality, together with their determinants, in a population-based cohort of Turner syndrome patients treated with GH in France.